SEMA4D compromises blood–brain barrier, activates microglia,

sma4dSEMA4D is an oncogene that functions in a variety of tumors, including colorectal carcinoma (14), cervical cancer (15), ovarian cancer (16), soft tissue carcinomas (17), oral cancer (18Sema4D, a member of the immune semaphorin family, plays crucial roles in the immune regulation, bone resorption and nervous system. It is also involved in angiogenesis and tumour